The integrity of scholarly research has always been one of the most—if not the most—important pillars of academic publishing. Authenticity, accuracy and reliability have always been the bedrock of the industry and a source of great pride for those working within it. However, in recent times, as models have evolved, the way we publish and consume content has changed and the world has become more interconnected, we have witnessed the emergence of several significant threats to research integrity. Subsequently, the role of journal publishers has had to adapt as we defend ourselves against these threats and strive to maintain credibility. In this article, we examine a few of the challenges and threats that journal publishers are currently facing.